Sometimes it can happen that you have mail stuck in your mail queue stating:

status=deferred (delivery temporarily suspended: connect to 127.0.0.1[127.0.0.1]: Connection refused

This usually means that for some reason your content filter (amavisd) is not running.

The easiest way to check if amavisd-new is running is to issue:

ps -U clamav 

(for Mac OS X 10.4.x)

ps -U _amavisd 

(for Mac OS X 10.5.x)

among other things, you should see something along the lines of:

  2393  ??  S      0:17.20 amavisd (ch7-avail)
  2450  ??  S      0:16.82 amavisd (ch7-avail)
 17823  ??  Ss     0:26.18 amavisd (master)
 

If you don’t see amavisd in the list, then it isn’t running and you need to further investigate the issue.